03043nas a2200313   4500008004100000020002300041024001900064245015200083210006900235260001800304520201900322100001902341700002002360700001802380700001802398700002402416700001702440700002102457700002002478700002302498700002602521700001702547700002302564700002302587700002502610700002602635700002302661856004502684       2017                        eng d  a1399-30621398-2273  ad1d, 10088368800aHerpes simplex virus-2 transmission following solid organ transplantation: Donor-derived infection and transplantation from prior organ recipients.0 aHerpes simplex virus2 transmission following solid organ transpl  aDenmarkc20173 aBACKGROUND: Owing to limited availability of donor organs, previous solid organ transplant (SOT) recipients are increasingly considered as potential organ donors. We report donor-derived transmission of herpes simplex virus type-2 (HSV-2) to two clusters of SOT recipients with transmission from the original donor and an HSV-2-infected recipient who subsequently became a donor., METHODS: We reviewed medical records of the donors and recipients in both clusters. Pre-transplant serology and virological features of HSV-2 were characterized. Genotyping of HSV-2 isolates to determine potential for donor transmission of HSV-2 through transplantation of organs from prior organ recipients was performed., RESULTS: A kidney-pancreas recipient died day 9 post transplant. Following confirmation of brain death, the lungs and recently transplanted kidney were donated to two further recipients. The liver was not retrieved, but biopsy confirmed HSV-2 infection. Testing on the original donor showed negative HSV-2 polymerase chain reaction and HSV immunoglobulin (Ig)M, but positive HSV-2 IgG. The liver recipient from the original donor developed HSV-2 hepatitis and cutaneous infection that responded to treatment with intravenous acyclovir. In the second cluster, lung and kidney recipients both developed HSV-2 viremia that was successfully treated with antiviral therapy. Genotyping of all HSV-2-positive samples showed 100% sequence homology for three recipients., CONCLUSIONS: Donor-derived HSV infection affected two clusters of recipients because of transplantation of organs from a prior organ recipient. HSV should be considered as a possible cause of illness in febrile SOT recipients in the immediate post-transplant period and may cause disseminated disease and re-infection in HSV-2-seropositive recipients. Testing of HSV serology and prophylaxis may be considered in SOT recipients not receiving cytomegalovirus prophylaxis.Copyright © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.1 aMacesic, Nenad1 aAbbott, Iain, J1 aKaye, Matthew1 aDruce, Julian1 aGlanville, Allan, R1 aGow, Paul, J1 aHughes, Peter, D1 aKorman, Tony, M1 aMulley, William, R1 aO'Connell, Phillip, J1 aOpdam, Helen1 aParaskeva, Miranda1 aPitman, Matthew, C1 aSetyapranata, Stella1 aRawlinson, William, D1 aJohnson, Paul, D R  uhttp://613633.bywedr.asia/reference/4593