01850nas a2200157   4500008003900000245011600039210006900155300001100224520134200235100001301577700001501590700001601605700001201621700001401633856004501647       2015                          d00aRespiratory Failure due to Possible Donor-Derived Sporothrix schenckii Infection in a Lung Transplant Recipient0 aRespiratory Failure due to Possible DonorDerived Sporothrix sche  a9257183 aBACKGROUND:

De novo and donor-derived invasive fungal infections (IFIs) contribute to morbidity and mortality in solid organ transplant (SOT) recipients. Reporting of donor-derived IFIs (DDIFIs) to the Organ Procurement Transplant Network has been mandated since 2005. Prior to that time no systematic monitoring of DDIFIs occurred in the United States.
CASE PRESENTATION:

We report a case of primary graft dysfunction in a 49-year-old male lung transplant recipient with diffuse patchy bilateral infiltrates likely related to pulmonary Sporothrix schenckii infection. The organism was isolated from a bronchoalveolar lavage on the second day after transplantation. Clinical and radiographic responses occurred after initiation of amphotericin B lipid formulation.
CONCLUSION:

We believe that this was likely a donor-derived infection given the early timing of the Sporothrix isolation after transplant in a bilateral single lung transplant recipient. This is the first case report of sporotrichosis in a lung transplant recipient. Our patient responded well to amphotericin induction therapy followed by maintenance therapy with itraconazole. The implications of donor-derived fungal infections and Sporothrix in transplant recipients are reviewed. Early recognition and management of these fungi are essential in improving outcomes.1 aBahr, NC1 aJanssen, K1 aBillings, J1 aLoor, G1 aGreen, JS  uhttp://613633.bywedr.asia/reference/4647