01858nas a2200241   4500008003900000245007400039210006900113260000800182520109800190653003601288653003301324653003601357653002301393653002301416653003901439100001601478700001501494700001901509700001501528700001601543700001201559856004501571       2017                          d00aDonor derived Kaposi's sarcoma in a liver-kidney transplant recipient0 aDonor derived Kaposis sarcoma in a liverkidney transplant recipi  cSep3 aHuman herpes virus 8 (HHV-8), also known as Kaposi's sarcoma associated herpesvirus (KSHV), is an oncogenic virus that can cause Kaposi's sarcoma (KS). KS can develop following organ transplantation through reactivation of the recipient's latent HHV-8 infection, or less commonly through donor-derived infection which has higher risk for severe illness and mortality. We describe a case of probable donor-derived KS in the recipient of a liver-kidney transplant. The donor had multiple risk factors for HHV-8 infection. The KS was successfully treated by switching immunosuppression from tacrolimus to sirolimus. With an increasing number of human immunodeficiency virus (HIV)-positive persons seeking organ transplantation and serving as organ donors for HIV-positive recipients, HHV-8 prevalence among donors and recipients will likely increase and with that the risk for post-transplant KS. Predetermination of HHV-8 status can be useful when considering organ donors and recipients with risk factors, although there are currently no validated commercial tests for HHV-8 antibody screening.10acancer / malignancy / neoplasia10aclinical research / practice10ainfection and infectious agents10ainfectious disease10aKaposi’s sarcoma10aviral: human herpesvirus 8 (HHV-8)1 aDollard, SC1 aDouglas, D1 aBasavaraju, SV1 aSchmid, DS1 aKuehnert, M1 aAqel, B  uhttp://613633.bywedr.asia/reference/4658