02535nas a2200313   4500008003900000245007800039210006900117260000800186520166500194653002901859653002301888653002901911100001601940700001901956700001901975700001201994700001402006700001102020700001902031700001702050700001602067700001702083700001502100700001402115700001602129700001402145700001702159856004502176       2017                          d00aMycoplasma hominis Infections Transmitted Through Amniotic Tissue Product0 aMycoplasma hominis Infections Transmitted Through Amniotic Tissu  cMay3 aBackground:

Mycoplasma hominis is a commensal genitourinary tract organism that can cause infections outside the genitourinary tract. We investigated a cluster of M. hominis surgical site infections in patients who underwent spine surgery, all associated with amniotic tissue linked to a common donor.
Methods:

Laboratory tests of tissue product from the donor, including culture, quantitative real-time PCR (qPCR), and whole genome sequencing were performed. Use of this amniotic tissue product was reviewed. A multi-state investigation to identify additional cases and locate any unused products was conducted.
Results:

Twenty-seven tissue product vials from a donor were distributed to facilities in seven states; at least 20 vials from this donor were used in 14 patients. Of these, 4/14 (29%) developed surgical site infections, including two M. hominis infections. M. hominis was detected by culture and qPCR in two unused vials from the donor. Sequencing indicated >99% similarity between patient and unopened vial isolates. For five of 27 (19%) vials, the final disposition could not be confirmed.
Conclusions:

M. hominis was transmitted through amniotic tissue from a single donor to two recipients. Current routine donor screening and product testing does not detect all potential pathogens. Clinicians should be aware that M. hominis can cause surgical site infections, and may not be detected by routine clinical cultures. The lack of a standardized system to track tissue products in healthcare facilities limits the ability of public health agencies to respond to outbreaks and investigate other adverse events associated with these products.10adonor-derived infections10aMycoplasma hominis10asurgical site infections1 aNovosad, SA1 aBasavaraju, SV1 aAnnambhotla, P1 aMohr, M1 aHalpin, A1 aFoy, L1 aChmielewski, R1 aWinchell, JM1 aBenitez, AJ1 aMorrison, SS1 aJohnson, T1 aCrabb, DM1 aRatliff, AE1 aWaites, K1 aKuehnert, MJ  uhttp://613633.bywedr.asia/reference/4660