01957nas a2200193   4500008003900000245010100039210007100140260000800211490000700219520139100226100001401617700001401631700001301645700001401658700001601672700001401688700001601702856004501718       2019                          d00aOutcomes and risk factors of transfusion‐associated circulatory overload: a case control study0 aOutcomes and risk factors of transfusion‐associated circulatory   cJan0 v593 aBACKGROUND:  Transfusion-associated circulatory overload (TACO) is a growing concern in clinical practice. STUDY DESIGN AND METHODS:  A case control study was performed at the Nîmes University Hospital, France. TACO cases occurring after RBC transfusion reported from January 1, 2014, to May 31, 2017, were included as cases. Four controls by case were randomly selected among the other RBC recipients on the same day. RESULTS:  During the study period, 60 TACO diagnoses were reported for 37,029 transfused RBCs to a total of 8787 patients; 240 controls were included. The average rate of TACO was one case every 616 RBCs transfused. One in 146 transfused patients experienced TACO. TACO was associated with a higher 28-day mortality (22% vs. 11%; p = 0.003), and a longer hospital stay compared with controls (23.5 ± 19.6 days vs. 15.9 ± 20.1 days; p < 0.001). Four risk factors were independently associated with TACO in multivariable analysis: chronic use of loop diuretics (odds ratio [OR], 6.5, 95% confidence interval [CI], 3.3-12.9), hemorrhagic shock (OR, 12; 95% CI, 2.9-50), body weight <46 kg (OR, 7.9; 95% CI, 2.3-26.8) and chronic hypertension (OR, 4.1; 95% CI, 2-8.5). CONCLUSION:  TACO was frequent and associated with poor outcome. Four independent risk factors were identified: hemorrhagic shock, low body weight, chronic use of diuretics, and chronic hypertension.1 aDaurat, A1 aGrenie, J1 aRoger, C1 aDaurat, G1 aCuvillon, P1 aMuller, L1 aLefrant, JY  uhttp://613633.bywedr.asia/reference/4822