01958nas a2200169   4500008003900000245011900039210006900158260000800227300000600235490000700241520144500248100000501693700001501698700001401713700001601727856004501743       2019                          d00aSevere CD4+ T-cell lymphopenia is not observed in frequent plateletpheresis donors collected on the Fenwal Amicus.0 aSevere CD4 Tcell lymphopenia is not observed in frequent platele  cSep  a30 v593 aBackground: In a recent study, we determined that 30% of frequent plateletpheresis donors collected using the Trima Accel Automated Blood Collection System (Terumo BCT) had a CD4+ T-cell count below 200 cells/μL. Whether CD4+ T-cell lymphopenia is associated with donation using other plateletpheresis instruments is unknown.

Study design and methods: We obtained blood samples from 30 current frequent Fenwal Amicus plateletpheresis donors. All participants had made 20 to 24 plateletpheresis donations in the most recent 365-day period, and all had previously donated over 50 times on the Fenwal Amicus instrument. Blood samples were analyzed to determine blood counts, including CD4+ and CD8+ counts.

Results: Of 30 study participants, none had a CD4+ count below 200 cells/μL. There was one participant with a CD4+ count between 200 and 300 cells/μL. This individual was over the age of 55 and had a history of more than 300 lifetime plateletpheresis sessions. One participant had a CD8+ count below the lower limit of normal (125 cells/μL) and a normal CD4+ count.

Conclusion: We did not detect severe CD4+ lymphopenia in frequent platelet donors undergoing plateletpheresis with the Fenwal Amicus. Since the Fenwal Amicus does not incorporate a leukoreduction system chamber, this finding supports the hypothesis that such chambers-found in the Trima Accel instrument-contribute to CD4+ lymphopenia in frequent platelet donors.1 a1 aNeuberg, D1 aMakar, RS1 aKaufman, RM  uhttp://613633.bywedr.asia/reference/5060