01911nas a2200157   4500008003900000245011500039210006900154300000700223490000700230520141100237100001301648700001701661700001701678700001301695856004501708       2015                          d00aThe risk of transmitting cutaneous malignancy through skin transplantation: a literature-based risk assessment0 arisk of transmitting cutaneous malignancy through skin transplan  a030 v163 aAccording to the European Union Tissues and Cells Directives donation of tissue is contraindicated in the presence of or a previous history of malignant disease, with the exception of cutaneous basal cell carcinoma. Skin cancer is the most common cancer. Due to ultraviolet light exposure and increasing life expectancy an increasing prevalence of malignant or premalignant skin lesions is observed, which may result in a decline of the availability of skin for transplantation. A risk assessment based on published studies and expert opinion was performed in order to investigate the risk of transmitting malignant or premalignant skin lesions through tissue transplantation, and more particular through skin transplantation. The scarcity of data concerning cancer transmission in tissue transplantation was challenging. Circumstantial evidence, available for organ transplantation, was used to develop the following policy proposal for skin transplantation and cutaneous tumours. Malignant melanoma is an absolute contraindication for the donation of skin and also of other tissues, whereas, non-lesional skin and other tissues of a donor with non-melanoma skin cancer (basal cell and squamous cell carcinoma) or with a premalignant skin lesion can be considered for transplantation. The above mentioned protocol proposal might serve as a prototype for analogous protocols for non-cutaneous malignancies.1 aBosma, S1 aVan Wijk, MJ1 aRichters, CD1 aBeele, H  uhttp://613633.bywedr.asia/reference/5088