02677nas a2200337   4500008004100000022004200041245008100083210006900164250001000233260001000243300001300253490000700266520173000273653002302003653001902026653001102045653001102056653001002067653000902077653003002086653003002116653002002146100001602166700001802182700002502200700001502225700001702240700001902257700001802276856004502294       2008                        eng d  a0041-1337 (Print) 0041-1337 (Linking)00aThe Italian multiorgan donor cancer screening protocol: 2002-2005 experience0 aItalian multiorgan donor cancer screening protocol 20022005 expe  a39613  c46478  aS57 - 600 v853 aBACKGROUND: We describe the results of the application of the Italian donor cancer screening protocol to all the 7608 candidate multiorgan donors presented in Italy in 2002-2005. METHODS: All suspect findings raised in the two presurgical and surgical phases of the protocol were investigated by extemporary pathologic evaluation. Donors were classified as standard risk (no transmissible risk); nonstandard risk (low-risk of transmission, eligibility restricted to certified clinical emergencies pending informed consent); and unacceptable risk (unconditional exclusion because of high-risk pathologies). RESULTS: The protocol was successfully implemented for all 7608 candidates. In addition to 8 (0.1%) independent exclusions, clinical suspicion of cancer was raised for 337 (4.6%) donors. According to pathological examination 198 donors (2.6%) were judged at unacceptable risk of tumor transmission; 80 (1%) were included in the "standard risk". Used standard risk and nonstandard risk donors provided a total of 241 organs in 231 recipients. Although no suspect was raised after implementation of the protocol, a malignant tumor was discovered after organ transplantation in 14 (0.2%) donors. All the recipients transplanted with organs from ascertained nonstandard risk donors or from neoplastic donors who donated by accident have been carefully followed. At the time of most recent follow-up no donor/recipient tumor transmission has been reported. CONCLUSIONS: Implementation of the multiorgan cancer screening protocol is feasible at a national level in Italy. In view of the increasing demand for organs our protocol provides a useful tool for rationalization of the use of organs from neoplastic marginal donors.10a*Patient Selection10a*Tissue Donors10aFemale10aHumans10aItaly10aMale10aMass Screening / *methods10aNeoplasms / *epidemiology10aRisk Assessment1 aZucchini, N1 aFiorentino, M1 aD'Errico Grigioni, A1 aRizzato, L1 aVenettoni, S1 aNanni Costa, A1 aGrigioni, W F  uhttp://613633.bywedr.asia/reference/1685