02974nas a2200301   4500008004100000020001400041024001700055245010600072210006900178260031200247300001600559490000700575520179800582100001502380700001302395700001802408700001902426700001802445700001702463700002302480700001702503700002202520700001802542700002002560700002502580700002202605856004502627       2008                        eng d  a0041-1132  awdn, 041736000aThe American Red Cross donor hemovigilance program: complications of blood donation reported in 2006.0 aAmerican Red Cross donor hemovigilance program complications of   aCopyright (C) 2008 Blackwell Publishing Ltd.bFrom the Biomedical Services, Medical Office, National Headquarters, American Red Cross, Washington, DC; the Jerome H. Holland Laboratory, American Red Cross, Rockville, Maryland; the Lewis and Clark Region, American Red Cross, Salt Lake City, Utah; the Cc2008  a1809 - 18190 v483 aBACKGROUND: The American Red Cross (ARC) initiated a comprehensive donor hemovigilance program in 2003. We provide an overview of reported complications after whole blood (WB), apheresis platelet (PLT), or automated red cell (R2) donation and analyze factors contributing to the variability in reported complication rates in our national program., STUDY DESIGN AND METHODS: Complications recorded at the collection site or reported after allogeneic WB, apheresis PLT, and R2 donation procedures in 36 regional blood centers in 2006 were analyzed by univariate and multivariate logistic regression., RESULTS: Complications after 6,014,472 WB, 449,594 PLT, and 228,183 R2 procedures totaled 209,815, 25,966, and 12,282 (348.9, 577.5, and 538.3 per 10,000 donations), respectively, the vast majority of which were minor presyncopal reactions and small hematomas. Regional center, donor age, sex, and donation status were independently associated with complication rates after WB, PLT, and R2 donation. Seasonal variability in complications rates after WB and R2 donation correlated with the proportion of donors under 20 years old. Excluding large hematomas, the overall rate of major complications was 7.4, 5.2, and 3.3 per 10,000 collections for WB, PLT, and R2 procedures, respectively. Outside medical care was recorded at similar rates for both WB and automated collections (3.2 vs. 2.9 per 10,000 donations, respectively)., CONCLUSION: The ARC data describe the current risks of blood donation in a model multicenter hemovigilance system using standardized definitions and reporting protocols. Reported reaction rates varied by regional center independently of donor demographics, limiting direct comparison of different regional blood centers., Copyright (C) 2008 Blackwell Publishing Ltd.1 aEder, Anne1 aDy, Beth1 aKennedy, Jean1 aNotari, Edward1 aStrupp, Annie1 aWissel, Mary1 aReddy, Ramakrishna1 aGibble, Joan1 aHaimowitz, Marcia1 aNewman, Bruce1 aChambers, Linda1 aHillyer, Christopher1 aBenjamin, Richard  uhttp://613633.bywedr.asia/reference/4011