02233nas a2200253   4500008004100000020001400041024001700055245010600072210006900178260031000247300001400557490000700571520119500578653002601773653002801799653002401827100001401851700001301865700001301878700001401891700001501905700001401920856004501934       2007                        eng d  a0268-3369  abon, 870245900aTransmission of integrated human herpesvirus-6 in allogeneic hematopoietic stem cell transplantation.0 aTransmission of integrated human herpesvirus6 in allogeneic hema  aCopyright (C) 2007 Nature Publishing Groupb(1)Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist Hospital, Houston, TX, USA; (2)Department of Virology, Barts and The London NHS Trust, London, UK and (3)Division of Infection and Immunity, Centre for Virology, Royal Free andc2007  a563 - 5660 v403 aHuman herpesvirus 6 (HHV-6) viremia, as detected by polymerase chain amplification, occurs in approximately half of allogeneic hematopoietic stem cell transplant recipients. The significance of such viremia is incompletely understood, but HHV-6 encephalitis and bone marrow suppression are increasingly being recognized in patients with high viral DNA. We report two patients in whom donor-to-recipient transmission occurred through hematopoietic transplant by means of chromosomally integrated (CI) HHV-6. Iatrogenic transmission manifested at engraftment as asymptomatic elevation of HHV-6 viral DNA of 3600 and 15 400 DNA copies/ml in plasma and 6.1 x 106 and 9.7 x 105 DNA copies/ml in the whole blood. Both donors had elevated plasma HHV-6 PCR at 5.6 x 104 and 1.3 x 105 DNA copies/ml and strikingly elevated whole blood HHV-6 levels at 4.1 x 106 and 4.7 x 106 DNA copies/ml, respectively. CI of the virus was traced to the mother of one patient and his donor. CI of HHV-6 may confound the interpretation of HHV-6 viremia after stem cell transplantation; consideration of the possibility of CI HHV-6 will avoid unnecessary antiviral therapy., Copyright (C) 2007 Nature Publishing Group10aallogeneic transplant10achromosomal integration10ahuman herpesvirus-61 aKamble, R1 aClark, D1 aLeong, H1 aHeslop, H1 aBrenner, M1 aCarrum, G  uhttp://613633.bywedr.asia/reference/4076