02209nas a2200241   4500008004100000020001400041024001700055245010700072210006900179260016700248300001200415490000700427520129100434653003101725653003601756653002301792100002401815700002301839700001901862700002001881700002101901856004501922       1999                        eng d  a1077-4114  a9505928, b5700aAnti-s Antibody-Associated Delayed Hemolytic Transfusion Reaction in Patients With Sickle Cell Anemia.0 aAntis AntibodyAssociated Delayed Hemolytic Transfusion Reaction   a(C) 1999 Lippincott Williams & Wilkins, Inc.bFrom the Department of Pediatrics, Children's Hospital of Michigan, Wayne State University, Detroit, MI 48201.c1999  a70 - 730 v213 aPurpose: Signs and symptoms of delayed hemolytic transfusion reaction (DHTR) may resemble those of vaso-occlusive crises in patients with sickle cell anemia (SCA). The diagnosis of DHTR therefore presents a challenge to the clinician when treating such patients. The current study describes a patient with SCA and DHTR secondary to red cell anti-s antibody, manifesting as painful extremeties, severe hemolytic anemia, and acute oliguric renal failure., Patient and Methods: A 17-year-old patient with homozygous hemoglobin S presented 8 days after partial exchange transfusions with severe anemia and signs and symptoms resembling vaso-occlusive crisis. Clinical course was complicated by intravascular hemolysis and acute renal failure., Results: Anti-s antibody was detected in the eluate. Diagnosis of DHTR was made. Treatment included single volume whole blood exchange transfusion and continuous veno-venous hemofiltration with dialysis., Conclusions: The possibility of DHTR should be considered in a patient with SCA with hemolytic anemia. Acute renal failure is a rare complication of anti-s antibody-associated DHTR. Such reactions can be successfully managed with exchange transfusion and continuous hemofiltration with dialysis., (C) 1999 Lippincott Williams & Wilkins, Inc.10aDirect anti-globulin test.10aHemolytic transfusion reactions10aSickle cell anemia1 aKalyanaraman, Meena1 aHeidemann, Sabrina1 aSarnaik, Ashok1 aMeert, Kathleen1 aSarnaik, Sharada  uhttp://613633.bywedr.asia/reference/4136