02597nas a2200217   4500008004100000020001400041024001700055245012700072210006900199260028100268300001300549490000800562520163100570100001802201700001802219700002602237700002902263700001902292700002302311856004502334       2015                        eng d  a1528-0020  aa8g, 760350900aPlatelet transfusions in platelet consumptive disorders are associated with arterial thrombosis and in-hospital mortality.0 aPlatelet transfusions in platelet consumptive disorders are asso  aUnited StatesbGoel,Ruchika. Division of Transfusion Medicine, Department of Pathology, and Division of Pediatric Hematology, Johns Hopkins University, Baltimore, MD; and.Ness,Paul M. Division of Transfusion Medicine, Department of Pathology, and.Takemoto,Clifford M. Dic2015  a1470 - 60 v1253 aWhile platelets are primary mediators of hemostasis, there is emerging evidence to show that they may also mediate pathologic thrombogenesis. Little data are available on risks and benefits associated with platelet transfusions in thrombotic thrombocytopenic purpura (TTP), heparin-induced thrombocytopenia (HIT) and immune thrombocytopenic purpura (ITP). This study utilized the Nationwide Inpatient Sample to evaluate the current in-hospital platelet transfusion practices and their association with arterial/venous thrombosis, acute myocardial infarction (AMI), stroke, and in-hospital mortality over 5 years (2007-2011). Age and gender-adjusted odds ratios (adjOR) associated with platelet transfusions were calculated. There were 10 624 hospitalizations with TTP; 6332 with HIT and 79 980 with ITP. Platelet transfusions were reported in 10.1% TTP, 7.1% HIT, and 25.8% ITP admissions. Platelet transfusions in TTP were associated with higher odds of arterial thrombosis (adjOR = 5.8, 95%CI = 1.3-26.6), AMI (adjOR = 2.0, 95%CI = 1.2-3.3) and mortality (adjOR = 2.0,95%CI = 1.3-3.0), but not venous thrombosis. Platelet transfusions in HIT were associated with higher odds of arterial thrombosis (adjOR = 3.4, 95%CI = 1.2-9.5) and mortality (adjOR = 5.2, 95%CI = 2.6-10.5) but not venous thrombosis. Except for AMI, all relationships remained significant after adjusting for clinical severity and acuity. No associations were significant for ITP. Platelet transfusions are associated with higher odds of arterial thrombosis and mortality among TTP and HIT patients. Copyright © 2015 by The American Society of Hematology.1 aGoel, Ruchika1 aNess, Paul, M1 aTakemoto, Clifford, M1 aKrishnamurti, Lakshmanan1 aKing, Karen, E1 aTobian, Aaron, A R  uhttp://613633.bywedr.asia/reference/4194