Record number:
1063
Adverse Occurrence type:
MPHO Type:
Time to detection:
3 weeks
Alerting signals, symptoms, evidence of occurrence:
Symptomatic anemia (hemoglobin 4.5 g/dL, reticulocyte count 0.2%) and anti-PV-B19 IgM and IgG seroconversion in a 14-yr-old male kidney recipient. Non-oliguric acute renal failure after the administration of a high sucrose content IVIg preparation for PV-B19 induced pure red cell aplasia.
Demonstration of imputability or root cause:
In an effort to trace the source of the infection, the patient’s serum from
the pretransplant final cross-match was evaluated and found to be negative for antibodies against parvovirus B19. Unfortunately, no serum was available from the donor for PV-B19 testing. Given this, the authors conclude that it is possible that the recipient may have been infected either from the donor or post-transplant by respiratory transmission.
Imputability grade:
1 Possible
Suggest references:
Subtirelu MM, Flynn JT, Schechner RS, et al. Acute renal failure in a pediatric kidney allograft recipient treated with intravenous immunoglobulin for parvovirus B19 induced pure red cell aplasia. Pediatr Transplant. 2005 Dec;9(6):801-4.