Macroscopic (frank) haematuria due to IgA nephropathy

Status:

Ready to upload

Record number:

1798

Adverse Occurrence type:

MPHO Type:

Estimated frequency:

Uncommon

Time to detection:

Occurs during GCSF injections (although has been described to occur several days later in at least one case).

Alerting signals, symptoms, evidence of occurrence:

Haematuria

Demonstration of imputability or root cause:

Renal biopsy. Definite imputability (if biopsy-proven).

Imputability grade:

3 Definite/Certain/Proven

Groups audience:

Keywords:

G-CSF (granulocyte colony-stimulating factor)

IgA (immunoglobulin A)

PBSC (peripheral blood stem cells)

References:

Possible involvement of G-CSF in IgA nephropathy developing in an allogeneic peripheral blood SCT donor.

Exacerbation of IgA nephropathy following G-CSF administration for PBSC collection: suggestions for better donor screening.

Reference attachment:

IgA nephropathy following G-CSF administration, Lee 2016.pdf

Suggest references:

1) Lee JB, Billen A, et al. Exacerbation of IgA nephropathy following G-CSF administration for PBSC collection: suggestions for better donor screeningBone Marrow Transplant. 2016 Feb;51(2):286-7. 2) Funakoshi, Y, Nazneen A, et al. Possible involvement of G-CSF in IgA nephropathy developing in an allogeneic peripheral blood SCT donor. Bone Marrow Transplant, 2010, Volume 45, Issue 9, p.1477 - 1478

Note:

The WMDA annual report 2015 should be added to record 501(Bronwen)

Expert comments for publication:

Uncommon although documented causal link of haematuria provoked by GCSF injection due to underlying IgA nephropathy.