Record number:
263
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
Most recent risk assessment for Lung Cancer (Council of Europe, 2022): Any histotype of newly-diagnosed lung cancer is an unacceptable risk for organ donation. Lung cancer in the donor history: Treated lung cancer is considered to be associated with a high transmission risk. Risk may decrease after curative therapy, with recurrence-free time and with increasing probability of cure.
Time to detection:
32 months
Alerting signals, symptoms, evidence of occurrence:
32 months after Tx, the recipient presents with a Cushing syndrome. Ultrasound of the transplanted kidney showed a mass found to be a small cell lung carcinoma. She had an extensive disease involving the kidney and the retroperitoneum. Alive in dialysis after nephrectomy and chemotherapy.
Demonstration of imputability or root cause:
Donor diagnosed of a small cell carcinoma of the lung 10 months after donation-transplantation. HLA typing of the patient and living related kidney donor performed: tumor tissue from the kidney mass stained with an antibody specific for the HLA-A2 antigen, expressed by the donor and not the recipient.
Imputability grade:
3 Definite/Certain/Proven
Groups audience:
References:
Suggest new keywords:
Case report
Living donor
Kidney transplant
Lung cancer, small cell
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Expert comments for publication:
At last reported followup (12 months) patient was in remission following cisplatin etoposide chemotherapy.