| Title | Absence of neuroinvasive disease in a liver transplant recipient who acquired West Nile virus (WNV) infection from the organ donor and who received WNV antibodies prophylactically |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Morelli MC, Sambri V, Grazi GL, Gaibani P, Pierro A, Cescon M, Ercolani G, Cavrini F, Rossini G, Capobianchi MR, Di Caro A, Menzo S, Pagliaro PP, Ghinelli F, Lazzarotto T, Landini MP, Pinna AD |
| Journal | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America |
| Volume | 51 |
| Issue | 4 |
| Pagination | e34 - 7 |
| Date Published | Aug 15 |
| Type of Article | Case Reports Research Support, Non-U.S. Gov't |
| ISSN | 1537-6591 (Electronic) 1058-4838 (Linking) |
| Accession Number | 20597692 |
| Keywords | *Disease Transmission, Infectious, Adult, Aged, Antibodies, Viral / *therapeutic use, Chemoprevention / *methods, Europe, Female, Humans, Immunization, Passive / methods, Immunoglobulins, Intravenous / therapeutic use, Liver Transplantation / adverse effects, Tissue Donors, Transplantation, West Nile Fever / drug therapy / *prevention & control, West Nile virus / immunology / *isolation & purification |
| Abstract | We describe the first case of West Nile virus (WNV) infection in Europe with transmission from donor to recipient following liver transplantation. The infection was detected in the recipient 3 days after transplantation, during the asymptomatic phase. We also report an innovative prophylactic strategy based on infusion of WNV hyperimmune plasma and gamma globulins that could be effective in preventing the appearance of a neuroinvasive disease. |
| DOI | 10.1086/655146 |
| Alternate Journal | Clin Infect Dis |
| Notify Library Reference ID | 1038 |
Absence of neuroinvasive disease in a liver transplant recipient who acquired West Nile virus (WNV) infection from the organ donor and who received WNV antibodies prophylactically
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