Status:
Ready to upload
Record number:
1491
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
0.9% TRALI cases in the population screened
Time to detection:
118 minutes (mean)
Alerting signals, symptoms, evidence of occurrence:
The mean time interval between initiation of transfusion and onset of symptoms was 118 minutes. Suspected TRALI was defined as new-onset of hypoxia or deterioration defined as Pao2/Fio2 ratio less than 300 mm Hg (or Spo2/Fio2 ratio < 250 when Spo2 < 97% if no arterial catheter was present), within 6 hours of transfusion with bilateral pulmonary infiltrates on the chest radiographs in the absence of cardiogenic pulmonary edema. Cardiogenic pulmonary edema was excluded either clinically or by echocardiogram.
Demonstration of imputability or root cause:
Canadian Consensus Conference TRALI criteria
Imputability grade:
2 Probable
Groups audience:
Keywords:
Suggest references:
Mulder HD, Augustijn QJ, van Woensel JB, Bos AP, Juffermans NP, Wösten-van Asperen RM. Incidence, risk factors, and outcome of transfusion-related acute lung injury in critically ill children: a retrospective study. J Crit Care. 2015 Feb;30(1):55-9
Expert comments for publication:
The incidence in the pediatric intensive care unit population is similar to that in adult intensive care unit patients. Nevertheless, high PRISM III score upon admission, sepsis, and requirement for mechanical ventilation risk factors were identified as independent factors for the development of TRALI.