Status:
Ready to upload
Record number:
1492
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
Anti-HLA class I/II antibodies or granulocyte-reactive anti-HLA antibodies were detected in 182% of blood components (RBC and FFP) transfused to TRALI and in 05% of FFP transfused to TAD cases. Cytokines and LysoPCs concentrations in blood components transfused to Pulmonary Transfusion Reactions including TRALI, TACO and TAD (PTR) patients, did not exceed those in blood components transfused to patients with no PTR. Only EMPs percentage in RBCs transfused to patients with TRALI was significantly higher (P < 005) than in RBCs transfused to patients with no PTR.
Alerting signals, symptoms, evidence of occurrence:
464 blood components transfused to 271 patients who then developed TRALI, TACO, TAD evaluated for immune and non immune factors role in the pathogenesis.
Demonstration of imputability or root cause:
Criteria of TRALI, TACO and TAD were according to the ISBT definitions for non-infectious transfusion reactions
Imputability grade:
2 Probable
Groups audience:
Keywords:
Suggest references:
Maślanka K, Uhrynowska M, Łopacz P, Wróbel A, Smoleńska-Sym G, Guz K, Lachert E, Ostas A, Brojer E. Analysis of leucocyte antibodies, cytokines,lysophospholipids and cell microparticles in blood components implicated in post-transfusion reactions with dyspnoea. Vox Sang. 2015 Jan;108(1):27-36