Transfusion-transmitted hepatitis E in Germany, 2013.

TitleTransfusion-transmitted hepatitis E in Germany, 2013.
Publication TypeJournal Article
Year of Publication2014
AuthorsHuzly D, Umhau M, Bettinger D, Cathomen T, Emmerich F, Hasselblatt P, Hengel H, Herzog R, Kappert O, Maassen S, Schorb E, Schulz-Huotari C, Thimme R, Unmussig R, Wenzel JJ, Panning M
JournalEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin//Euro Surveill
Volume19
Issue21
Date Published2014
ISBN Number1560-7917
Other Numbers100887452
Keywords*Blood Transfusion/ae [Adverse Effects], *Hepatitis E virus/ip [Isolation & Purification], *Hepatitis E/bl [Blood], *RNA, Viral/bl [Blood], Adult, Antibodies, Viral/bl [Blood], Blood Donors, Child, Contact Tracing, Germany, Hepatitis Antibodies/bl [Blood], Hepatitis E virus/ge [Genetics], Hepatitis E virus/im [Immunology], Hepatitis E/tm [Transmission], Hepatitis E/vi [Virology], Humans, Immunoglobulin G/bl [Blood], Retrospective Studies, Reverse Transcriptase Polymerase Chain Reaction, RNA, Viral/ge [Genetics]
Abstract

The reported IgG seroprevalence against hepatitis E virus (HEV) in German blood donations is 6.8%, and HEV RNA detected in 0.08%, but documented evidence for HEV transmission is lacking. We identified two donations from a single donor containing 120 IU HEV RNA/mL plasma and 490 IU/mL. An infectious dose of 7,056 IU HEV RNA was transmitted via apheresis platelets to an immunosuppressed patient who developed chronic HEV. Further, transmission was probable in an immunocompetent child.
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