| Title | Early and fatal immune haemolysis after so-called 'minor' ABO-incompatible peripheral blood stem cell allotransplantation |
| Publication Type | Journal Article |
| Year of Publication | 1997 |
| Authors | Oziel-Taieb S, Faucher-Barbey C, Chabannon C, Ladaique P, Saux P, Gouin F, Gastaut JA, Maraninchi D, Blaise D |
| Journal | Bone Marrow Transplantation |
| Volume | 19 |
| Issue | 11 |
| Pagination | 1155 - 6 |
| Date Published | Jun |
| Type of Article | Case Reports |
| ISSN | 0268-3369 (Print) 0268-3369 (Linking) |
| Accession Number | 9193761 |
| Keywords | *Hemolysis, ABO Blood-Group System / *immunology, Adult, Blood Group Incompatibility / *complications, Hematopoietic Stem Cell Transplantation / *adverse effects, Humans, Male, Transplantation, Homologous |
| Abstract | A 38-year-old man, blood group A+, was allotransplanted for multiple myeloma from his fully matched sister, blood group O+. Anti-A antibodies IgG and IgM titres of the donor were low. Allogeneic peripheral blood stem cells were harvested by leukapheresis after subcutaneous administration of G-CSF. Rapid engraftment occurred since 5.6 x 10(9)/l leukocytes were achieved on day +9 post-transplant. At this time a severe immune haemolytic syndrome occurred and direct antiglobulin test was positive (IgG and C3d). Elution showed an anti-A specificity. Evolution was rapidly unfavourable related to multiorgan failure. The patient died on day +20 post-transplant. |
| DOI | 10.1038/sj.bmt.1700794 |
| Alternate Journal | Bone Marrow Transplant |
| Notify Library Reference ID | 1117 |
