Herpes simplex virus 1 transmission through corneal transplantation

TitleHerpes simplex virus 1 transmission through corneal transplantation
Publication TypeJournal Article
Year of Publication2001
AuthorsRemeijer L, Maertzdorf J, Doornenbal P, Verjans GM, Osterhaus AD
JournalLancet
Volume357
Issue9254
Pagination442
Date Published40210
ISSN0140-6736 (Print) 0140-6736 (Linking)
Accession Number11273067
Keywords*Herpesvirus 1, Human / genetics / immunology, *Keratoplasty, Penetrating, Adult, Antibodies, Viral / blood, DNA Fingerprinting, Glaucoma / *congenital / surgery, Humans, Keratitis, Herpetic / immunology / *transmission / virology, Male, Polymerase Chain Reaction, Reoperation, Tissue Donors, Virus Activation
Abstract

Genetic characterisation of herpes simplex virus type 1 (HSV-1) DNA isolated from a donor cornea before and after corneal transplantation demonstrated the transmission of HSV-1 through transplantation. This study is the first to provide conclusive evidence for the transmission of HSV-1 by penetrating keratoplasty with subsequent reactivation of donor-derived HSV-1 in the transplanted cornea.
URLinternal-pdf://Remeijer et al Herpes Simplex 1 Virus-0797119233/Remeijer et al Herpes Simplex 1 Virus.pdf
DOI10.1016/S0140-6736(00)04011-3
Notify Library Reference ID1310

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