Spontaneous splenic rupture following administration of granulocyte colony-stimulating factor (G-CSF): occurrence in an allogeneic donor of peripheral blood stem cells

TitleSpontaneous splenic rupture following administration of granulocyte colony-stimulating factor (G-CSF): occurrence in an allogeneic donor of peripheral blood stem cells
Publication TypeJournal Article
Year of Publication1997
AuthorsBecker PS, Wagle M, Matous S, Swanson RS, Pihan G, Lowry PA, Stewart FM, Heard SO
JournalBiology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
Volume3
Issue1
Pagination45 - 9
Date PublishedApr
Type of ArticleCase Reports
ISSN1083-8791 (Print) 1083-8791 (Linking)
Accession Number9209740
Keywords*Blood Donors, *Hematopoietic Stem Cell Transplantation, *Tissue Donors, Acute Disease, Adult, Bone Marrow Transplantation, Diagnosis, Differential, effects, Fever / complications, Fusion Proteins, bcr-abl / analysis, Granulocyte Colony-Stimulating Factor / administration & dosage / *adverse, Hematopoiesis, Extramedullary / *drug effects, Hemoperitoneum / etiology, Herpesviridae Infections / diagnosis, Herpesvirus 4, Human / isolation & purification, Humans, Leukapheresis, Leukemia, Myelogenous, Chronic, BCR-ABL Positive / diagnosis, Leukemia, Myeloid / therapy, Male, Pneumothorax / complications, Recurrence, Respiratory Distress Syndrome, Adult / complications, Rupture, Spontaneous, Splenectomy, Splenic Rupture / *chemically induced / surgery, Splenomegaly / chemically induced / diagnosis, Transplantation, Homologous, Tumor Markers, Biological / analysis
Abstract

Granulocyte colony-stimulating factor (G-CSF) has been used to improve granulocyte count in chronic neutropenia and myelodysplasia, to minimize the incidence and duration of neutropenia during conventional chemotherapy, and to mobilize peripheral blood stem cells prior to leukapheresis for use in autologous and allogeneic marrow transplantation. The most common toxicity is bone pain, and other reactions such as inflammation at the site of injection have also occurred. In patients with chronic neutropenia, splenomegaly has been described with long-term use, and extramedullary hematopoiesis has also been reported. However, thus far, no life-threatening sequelae of these effects are found in the literature. We now describe a case of spontaneous splenic rupture four days following a six-day course of G-CSF therapy in an allogeneic donor of peripheral blood stem cells.
Alternate JournalBiol Blood Marrow Transplant
Notify Library Reference ID150

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