The incidence of recurrence of leukemia in donor cells after allogeneic bone marrow transplantation

TitleThe incidence of recurrence of leukemia in donor cells after allogeneic bone marrow transplantation
Publication TypeJournal Article
Year of Publication1982
AuthorsBoyd CN, Ramberg RC, Thomas ED
JournalLeuk Res
Volume6
Issue6
Pagination833 - 7
Accession Number6759797
Keywords*Bone Marrow Transplantation, Bone Marrow / pathology, Female, Humans, Leukemia / *therapy, Male, Research Support, U.S. Gov't, P.H.S., Transplantation, Homologous
Abstract

A total of 243 patients with acute leukemia received a marrow graft from a donor of the opposite sex. Seventy-five patients subsequently relapsed, and specimens of the recurrent leukemia cells were available for cytogenetic analysis in 54. Three relapses were in donor-type cells. Four patients whose relapses were in host-type cells showed a cytogenic abnormality that differed from the original leukemic clone. We conclude that a 'new' leukemia in donor cells, and possibly in host cells, constitutes a small but significant fraction of recurrent leukemia after marrow grafting.
Notify Library Reference ID215