Leukemia in donor cells after allogeneic hematopoietic stem cell transplant

TitleLeukemia in donor cells after allogeneic hematopoietic stem cell transplant
Publication TypeJournal Article
Year of Publication2002
AuthorsBrunstein CG, Hirsch BA, Hammerschmidt D, McGlennen RC, Nguyen PL, Verfaillie CM
JournalBone Marrow Transplant
Volume29
Issue12
Pagination999 - 1003
Date PublishedJun
Accession Number12098070
Keywords*Hematopoietic Stem Cell Transplantation, Adult, Cell Transformation, Neoplastic / genetics / pathology, Cytogenetic Analysis, Fatal Outcome, Humans, Leukemia, Lymphocytic, Chronic / pathology / *therapy, Leukemia, Myeloid / etiology / *genetics / pathology, Male, Minisatellite Repeats, Myelodysplastic Syndromes / pathology / therapy, Neoplasms, Second Primary / etiology / *genetics / pathology, Tissue Donors, Transplantation Chimera / genetics, Transplantation, Homologous
Abstract

The development of leukemia in donor cells after allogeneic hematopoietic stem cell transplant is an extremely rare event. We report here the case of a patient who developed myelodysplastic syndrome/acute myeloid leukemia, in cells of donor origin 3.5 years after related donor HSCT for refractory chronic lymphocytic leukemia and therapy-induced myelodysplastic syndrome. The origin of the leukemia was determined by analysis of minisatillite polymorphism tested on CD34(+) cells.
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