Prevalence and distribution of iron overload in patients with transfusion-dependent anemias differs across geographic regions: results from the CORDELIA study.

TitlePrevalence and distribution of iron overload in patients with transfusion-dependent anemias differs across geographic regions: results from the CORDELIA study.
Publication TypeJournal Article
Year of Publication2015
AuthorsAydinok Y, Porter J, Piga A, Elalfy M, El-Beshlawy A, Kilinc Y, Viprakasit V, Yesilipek A, Habr D, Quebe-Fehling E, Pennell D
Journal//Eur J Haematol
Date Published2015
ISBN Number0902-4441
Other Numberserf, 8703985
Keywordsdistribution, Heart, iron, Liver, Prevalence, thalassemia
Abstract

Objectives: The randomized comparison of deferasirox to deferoxamine for myocardial iron removal in patients with transfusion-dependent anemias (CORDELIA) gave the opportunity to assess relative prevalence and body distribution of iron overload in screened patients., Methods: Patients aged >=10 yr with transfusion-dependent anemias from 11 countries were screened. Data were summarized descriptively, overall and across regions., Results: Among 925 patients (99.1% with [beta]-thalassemia major; 98.5% receiving prior chelation; mean age 19.2 yr), 36.7% had myocardial iron overload (myocardial T2* =15 than

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